Male beset by his mature failing: joint pain (10)

I believe the answer is:

rheumatism

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'joint pain' is the definition.
The answer and definition can be both states of affairs as well as being singular nouns.
Perhaps you can see an association between them that I don't see?

'male beset by his mature failing' is the wordplay.
'male' becomes 'm' (common abbreviation).
'beset by' is an insertion indicator ('beset' could historically mean 'cover').
'failing' is an anagram indicator (a failed spelling of the word).
'his'+'mature'='hismature'
'hismature' with letters rearranged gives 'rheuatism'.
'm' put into 'rheuatism' is 'RHEUMATISM'.

Can you help me to learn more?

(Other definitions for rheumatism that I've seen before include "Inflammation of the joints" , "Joint affliction" , "ailment" .)

I've seen this clue in The Independent.

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