Male quarters in a minister's house (5)
I believe the answer is:
manse
'a minister's house' is the definition.
(house assigned to a religious minister)
'male quarters' is the wordplay.
'male' becomes 'man' (man is a kind of male).
'quarters' becomes 'se' (south and east, two compass quarters).
'man'+'se'='MANSE'
'in' is the link.
(Other definitions for manse that I've seen before include "Scottish minister's house" , "Religious home" , "Minister's quarters" , "House of a clergyman" , "Scottish minister's residence" .)