Males about to help girl (6)
I believe the answer is:
maiden
'girl' is the definition.
(I know that maiden is a type of girl)
'males about to help' is the wordplay.
'males' becomes 'men' (man is a kind of male).
'about' indicates putting letters inside.
'to help' becomes 'aid' ('aid' can be a synonym of 'help').
'men' placed around 'aid' is 'MAIDEN'.
(Other definitions for maiden that I've seen before include "No runs for the unmarried lady's over" , "No runs are scored from this - young girl" , "Of an aunt, unmarried" , "When you get her" , "Damsel" .)