Males running witch hunt site (5)
I believe the answer is:
salem
'witch hunt site' is the definition.
(site of Salem witch trials)
'males running' is the wordplay.
'running' indicates anagramming the letters (the letters run around to different places).
'males' is an anagram of 'SALEM'.
(Other definitions for salem that I've seen before include "trial scene" , "Witch trial town" , "Massachusetts city, scene of witch hunt" , "OT Hebrew capital" , "New England city, site of 1692 witchcraft trials" .)