Malice, removing quiet location (4)
I believe the answer is:
site
'location' is the definition.
(site is a kind of location)
'malice removing quiet' is the wordplay.
'malice' becomes 'spite' (synonyms).
'removing' suggests deleting specific letters.
'quiet' becomes 'p' (music symbol for 'piano', ie soft or quiet).
'spite' with 'p' taken away is 'SITE'.
(Other definitions for site that I've seen before include "setting" , "Designated place" , "station" , "Locate, position" , "Area set aside for building" .)