Malice, spite (5)
I believe the answer is:
venom
I believe this clue is a double definition.
'malice' is the first definition.
(I know that malice can be written as venom)
'spite' is the second definition.
(I know that spite can be written as venom)
(Other definitions for venom that I've seen before include "Poison - spite" , "acrimony" , "Toxic substance" , "Bitter malice" , "Poison; malice" .)