Man has left with spice (5)
I believe the answer is:
clove
'spice' is the definition.
(clove is a kind of spice)
'man has left' is the wordplay.
'man' becomes 'cove' (I've seen this in other clues).
'has' is an insertion indicator.
'left' becomes 'l' (common abbreviation).
'cove' placed around 'l' is 'CLOVE'.
'with' is the link.
(Other definitions for clove that I've seen before include "Garlic segment" , "Dried flower bud spice" , "Aromatic bud" , "caused separation" , "A small bulb as of garlic" .)