Man in trouble, with no love lost (6)
I believe the answer is:
butler
'man' is the definition.
(thesaurus)
'trouble with no love lost' is the wordplay.
'with no' indicates named letters should be taken away.
'love' becomes 'o' (In tennis, 'love' means 'zero').
'lost' is an anagram indicator.
'trouble' with 'o' removed is 'truble'.
'truble' anagrammed gives 'BUTLER'.
'in' acts as a link.
(Other definitions for butler that I've seen before include "Male domestic servant" , "in charge of port?" , "British novelist" , "Chief manservant of posh household" , "Head manservant of posh household" .)