Man includes South American beads (6)
I believe the answer is:
rosary
'beads' is the definition.
(rosary is a kind of beads)
'man includes south american' is the wordplay.
'man' becomes 'rory' (**).
'includes' means one lot of letters goes inside another.
'south american' becomes 'sa'.
'rory' enclosing 'sa' is 'ROSARY'.
(Other definitions for rosary that I've seen before include "Flower garden" , "String of devotional beads" , "Chaplet" , "Catholic's string of beads" , "String of prayer beads" .)