Man sent up hurt and isolated (8)
I believe the answer is:
detached
'isolated' is the definition.
(synonyms)
'man sent up hurt' is the wordplay.
I cannot quite see how this works, but
'man' could be 'che' and 'che' is present in the answer.
This may be the basis of the clue (or it may be nonsense).
'and' is the link.
Can you help me to learn more?
(Other definitions for detached that I've seen before include "Not committed, objective" , "Separate; aloof" , "Separated from - maybe a house" , "cut off" , "Clinical" .)