Maniacs, say, going in opposite directions (7)
I believe the answer is:
nutters
'maniacs' is the definition.
I don't know anything about this answer so I cannot judge whether this works.
'say going in opposite directions' is the wordplay.
'say' becomes 'utter' (to utter something is to speak or say it).
'going in' means one lot of letters goes inside another.
'opposite directions' becomes 'NS' (abbreviations for north and south).
'utter' placed within 'ns' is 'NUTTERS'.
Can you help me to learn more?
(Other definitions for nutters that I've seen before include "Crazy people (slang)" , "Crazy folk" , "Crazy people (sl.)" , "Test run for crazy or eccentric people" .)