Maniacs, say, going in opposite directions (7)
I believe the answer is:
nutters
'maniacs' is the definition.
I know nothing about this answer so I can't tell whether it can be defined by this definition.
'say going in opposite directions' is the wordplay.
'say' becomes 'utter' (to utter something is to say or speak it).
'going in' is an insertion indicator.
'opposite directions' becomes 'NS' (abbreviations for north and south).
'utter' put into 'ns' is 'NUTTERS'.
Can you help me to learn more?
(Other definitions for nutters that I've seen before include "Crazy people (slang)" , "Crazy folk" , "Crazy people (sl.)" , "Test run for crazy or eccentric people" .)