Manipulator jerks toe in a very big way (9)
I believe the answer is:
osteopath
'manipulator' is the definition.
(an osteopath manipulates bones)
'jerks toe in a very big way' is the wordplay.
'jerks' is an anagram indicator (I've seen 'jerk' mean this).
'in' means one lot of letters goes inside another.
'a very big' becomes 'os' (abbreviation for outsize).
'way' becomes 'path' (synonyms).
'toe' is an anagram of 'teo'.
'os'+'path'='ospath'
'teo' inserted inside 'ospath' is 'OSTEOPATH'.
(Other definitions for osteopath that I've seen before include "Health professional" , "Therapist who manipulates the skeleton" , "Shoot a pet (anag) - healer" , "Shot a poet (anag.)" , "Bonesetter" .)