Manual workers leave hotel to move sand (5)
I believe the answer is:
hands
'manual workers' is the definition.
(eg factory hands)
'hotel to move sand' is the wordplay.
'hotel' becomes 'h' (phonetic alphabet).
'to move' indicates anagramming the letters (I've seen 'moving' mean this).
'sand' anagrammed gives 'ands'.
'h'+'ands'='HANDS'
'leave' is the link.
(Other definitions for hands that I've seen before include "Workers" , "Crew members" , "Those holding harness" , "Players' cards" , "Measurements for horses" .)