Manufacturing lacks go in Pakistan (5)
I believe the answer is:
indus
'in pakistan' is the definition.
('Indus' is part of 'pakistan')
'manufacturing lacks go' is the wordplay.
'manufacturing' becomes 'industry' (synonyms).
'lacks' suggests deleting specific letters.
'go' becomes 'try' (both can mean an attempt).
'industry' with 'try' taken away is 'INDUS'.
(Other definitions for indus that I've seen before include "Important river" , "banker" , "River rising in Tibet" , "River of Southern Asia" , "South Asian river" .)