Manufacturing trouble east of river (10)
I believe the answer is:
industrial
'manufacturing' is the definition.
(thesaurus)
'trouble east of river' is the wordplay.
'trouble' becomes 'trial' (trial is a kind of trouble).
'east of' means one lot of letters go next to another (some letters go to the right of others).
'river' becomes 'indus' (Indian river).
'trial' put after 'indus' is 'INDUSTRIAL'.
(Other definitions for industrial that I've seen before include "fabricating things?" , "Involved in manufacture" , "Like some business" , "Like manufacturing" , "Characterised by manufacturing processes" .)