Many a trading centre is central! (3)
I believe the answer is:
mid
'is central' is the definition.
(thesaurus)
'many a trading centre' is the wordplay.
'many' becomes 'm' (Roman numeral for a thousand).
'a trading centre' becomes 'id' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'm'+'id'='MID'
Can you help me to learn more?
(Other definitions for mid that I've seen before include "Of the central part" , "Denote the centre point" , "Dim sort of prefix" , "Prefix meaning centre" .)