Many rats may be destroyed by these creatures (4,4)
I believe the answer is:
army ants
'these creatures' is the definition.
(army ant is a kind of creature)
'many rats may be' is the wordplay.
'may be' is an anagram indicator.
'many'+'rats'='manyrats'
'manyrats' anagrammed gives 'ARMY ANTS'.
'destroyed by' is the link.
I am not very happy about this link. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for army ants that I've seen before include "Foraging insects" , "Insects moving in large groups" .)