Many rushed, panicking, around in the quake (7)
I believe the answer is:
shudder
'quake' is the definition.
(shuddering is a kind of quaking)
'many rushed panicking around' is the wordplay.
'many' becomes 'D' (Roman numeral for 500).
'panicking' indicates an anagram.
'around' means one lot of letters goes inside another.
'rushed' anagrammed gives 'shuder'.
'd' going inside 'shuder' is 'SHUDDER'.
'in the' is the link.
(Other definitions for shudder that I've seen before include "Tremble through fear" , "Shake, quaver" , "Shiver in fear or revulsion" , "Convulsion" , "Convulse" .)