Mark runs through injury (6)
I believe the answer is:
strain
'injury' is the definition.
(thesaurus)
'mark runs' is the wordplay.
I cannot really understand how this works, but
'runs' could be 'r' (cricket abbreviation) and 'r' is located in the answer.
'mark' could be 'stain' (synonyms) and 'stain' is located in the leftover letters.
No letters remain.
This may be the basis of clue (or it may be nonsense).
'through' acts as a link.
Can you help me to learn more?
(Other definitions for strain that I've seen before include "Stretch or exert to the utmost" , "Injure (a muscle); distinct breed" , "Tension on trains" , "Music" , "Distinct breed; use a seive" .)