Married first man in woman's address (5)
I believe the answer is:
madam
'woman's address' is the definition.
(respectful term of address for a woman)
'married first man' is the wordplay.
'married first' becomes 'm' (ast letter of 'married').
'man' becomes 'adam' (Adam is an example).
'm'+'adam'='MADAM'
'in' is the link.
(Other definitions for madam that I've seen before include "Leader of House of Congress" , "Polite form of address for a woman" , "Bossy girl" , "Stuck-up girl" , "What you would call a female customer (or a spoiled girl!)" .)