Matchless pearl in no setting (9)
I believe the answer is:
nonpareil
'matchless' is the definition.
('nonpareil' can be a synonym of 'matchless')
'pearl in no setting' is the wordplay.
'setting' indicates an anagram.
'pearl'+'in'+'no'='pearlinno'
'pearlinno' anagrammed gives 'NONPAREIL'.
(Other definitions for nonpareil that I've seen before include "Super model" , "Unequalled" , "A variety of apple" , "Peerless" , "Unrivalled person/thing" .)