Matzo's lack (5)
I believe the answer is:
yeast
'matzo's lack' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for yeast that I've seen before include "As yet (anag)" , "It's put in to raise" , "Baker's raising agent" , "Fungus used in fermenting" , "Dough-raising agent" .)