May be vital even if you can't play it (5)
I believe the answer is:
organ
'it' is the definition.
The definition suggests a singular noun which matches the answer.
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for organ that I've seen before include "Pipe or reed instrument" , "Body part - musical instrument" , "Instrument - heart, for example" , "Wind instrument found in the body." , "specialist magazine" .)