Maybe eejit in California disheartened daughter-in-law, sending up drone (5)
I believe the answer is:
dweeb
'maybe eejit in california disheartened' is the definition.
I know nothing about this answer so I cannot tell whether this works.
'daughter-in-law sending up drone' is the wordplay.
'daughter' becomes 'd' (genealogical abbreviation).
'in law' becomes 'w' (I can't justify this - if you can you should give a lot more credence to this answer).
'sending up' is a reversal indicator (in a down clue, letters go up).
'drone' becomes 'bee' (drone is a type of bee).
'bee' written backwards gives 'eeb'.
'd'+'w'+'eeb'='DWEEB'
Can you help me to learn more?
(Other definitions for dweeb that I've seen before include "Geek" , "misfit" , "silly American" , "Nerd - wimp" , "techie bore?" .)