MDMA with powder taken up? Striking effect! (5)
I believe the answer is:
eclat
'striking effect' is the definition.
(I've seen this before)
'mdma with powder taken up?' is the wordplay.
'mdma with' becomes 'e' (I can't explain this - if you can you should believe this answer much more).
'powder' becomes 'talc' (talcing is a kind of powdering).
'taken up?' says the letters should be written in reverse.
'talc' written backwards gives 'clat'.
'e'+'clat'='ECLAT'
Can you help me to learn more?
(Other definitions for eclat that I've seen before include "Brilliant success - striking effect" , "Ceremonial elegance and splendour" , "Splash" , "great success" , "Brilliant display or effect" .)