Me always sick? There's a surprise (4,1,5)
I believe the answer is:
well i never
'sick? there's a surprise' is the definition.
I can't tell whether this definition defines the answer.
'me always' is the wordplay.
'me' becomes 'wellin' (I can't explain this - if you can you should believe this answer much more).
'always' becomes 'ever' ('ever' can be a synonym of 'always').
'wellin'+'ever'='WELL I NEVER'
(Other definitions for well i never that I've seen before include "Good gracious me!" , "Always sick, me?" , "That surprises me!" , "that comes as a great shock" , "Fancy that" .)