Me and my best friend? (6)
I believe the answer is:
setter
'me' is the definition.
(the person that set this crossword)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for setter that I've seen before include "Red - - , dog" , "Breed of gun dog" , "One barking" , "Silky-coated gun dog" , "Late evening sun is a" .)