Mean not to go out with nurse (6)
I believe the answer is:
intend
'mean' is the definition.
(to intend to something is to mean it)
'not to go out with nurse' is the wordplay.
'not to go out' becomes 'in' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'with' means one lot of letters go next to another.
'nurse' becomes 'tend' (tend can mean to nurse or look after).
'in'+'tend'='INTEND'
Can you help me to learn more?
(Other definitions for intend that I've seen before include "Have as purpose or plan" , "Purport" , "Mean; propose" , "Mean; aim" , "Have as purpose or in mind" .)