Mean to fix end toe (6)
I believe the answer is:
denote
'mean' is the definition.
(denoting is a kind of meaning)
'fix end toe' is the wordplay.
'fix' indicates anagramming the letters.
'end'+'toe'='endtoe'
'endtoe' with letters rearranged gives 'DENOTE'.
'to' acts as a link.
(Other definitions for denote that I've seen before include "Indicate, signify" , "Indicate, be a sign of" , "Mean or signify" , "Designate" , "show" .)