Memorise renal layout (5)
I believe the answer is:
learn
'memorise' is the definition.
(synonyms)
'renal layout' is the wordplay.
'layout' is an anagram indicator (an alternative layout of the letters).
'renal' with letters rearranged gives 'LEARN'.
(Other definitions for learn that I've seen before include "Comprehend" , "Gain knowledge or skill" , "Study or digest" , "Commit to memory" , "Succeed in school" .)