Mental weariness leads suit astray (9)
I believe the answer is:
lassitude
'mental weariness' is the definition.
'lassitude' can be an answer for 'weariness' (I've seen this before). I am not sure about the 'mental' bit.
'leads suit astray' is the wordplay.
'astray' indicates an anagram.
'leads'+'suit'='leadssuit'
'leadssuit' with letters rearranged gives 'LASSITUDE'.
Can you help me to learn more?
(Other definitions for lassitude that I've seen before include "Sluggishness" , "30 [LETHARGY]" , "Listlessness, lethargy" , "Listlessness, fatigue" , "Is saluted with tiredness" .)