Mike's misery over Persian remark? (4)
I believe the answer is:
meow
'persian remark?' is the definition.
(I've seen this in another clue)
'mike's misery over' is the wordplay.
'mike' becomes 'M' (phonetic alphabet: alpha, bravo, charlie etc.).
'misery' becomes 'woe' (woe is a kind of misery).
'over' is a reversal indicator.
'woe' reversed gives 'eow'.
'm'+'eow'='MEOW'
(Other definitions for meow that I've seen before include "Beastly noise" , "Tom's plea for attention" , "reply to spiteful dig" , "Crying sound of an animal" , "Cat's cry" .)