Mild expletive from female on edge (4)
I believe the answer is:
flip
'mild expletive' is the definition.
(flip is a mild curse word)
'female on edge' is the wordplay.
'female' becomes 'f' (abbreviation).
'on edge' becomes 'lip' (I've seen this before).
'f'+'lip'='FLIP'
'from' acts as a link.
(Other definitions for flip that I've seen before include "Not showing respect; turn over" , "Lose one's cool - reverse side" , "demanding > alcoholic drink" , "Turn (over) - impudent" , "Somersault; impertinent" .)