Minister realigned Pisa? Very droll! (4,5,4)
I believe the answer is:
lord privy seal
'minister' is the definition.
(Lord Privy Seal is an example)
'realigned pisa? very droll' is the wordplay.
'realigned' indicates anagramming the letters.
'pisa'+'very'+'droll'='pisaverydroll'
'pisaverydroll' anagrammed gives 'LORD PRIVY SEAL'.
(Other definitions for lord privy seal that I've seen before include "Top cabinet minister" , "minister's office" , "Senior cabinet minister" , "government office" , "Senior minister without portfolio, usually Leader of the House of Commons or Lords" .)