Minute deception nobbles sense (5)
I believe the answer is:
smell
'sense' is the definition.
(I know that sense can be written as smell)
'minute deception nobbles' is the wordplay.
I cannot quite see how this works, but
'minute' could be 'm' (abbreviation) and 'm' is found within the answer.
'deception' could be 'sell' (old-fashioned term for a hoax or con) and 'sell' is found within the leftover letters.
No letters remain.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for smell that I've seen before include "Nasal sense" , "stink" , "Scent" , "Unpleasant odour" , "Perceive through the nose" .)