Miscellany in large book needing no introduction (4)
I believe the answer is:
olio
'miscellany' is the definition.
(olio can mean a miscellany or mixture of things)
'large book needing no introduction' is the wordplay.
'large book' becomes 'folio' (I've seen this in another clue).
'needing no introduction' means to remove the first letter.
'folio' with its first letter removed is 'OLIO'.
'in' is the link.
(Other definitions for olio that I've seen before include "Variety" , "Mixture" , "Savoury dish of different types of meat and vegetable" , "Collection of miscellany" .)