Miserable male, one leaving without difficulty (6)
I believe the answer is:
measly
'miserable' is the definition.
(synonyms)
'male one leaving without difficulty' is the wordplay.
'male' becomes 'm' (common abbreviation).
'one' becomes 'i' (Roman numeral).
'leaving' indicates named letters should be taken away.
'without difficulty' becomes 'easily' (synonyms).
'easily' with 'i' taken out is 'easly'.
'm'+'easly'='MEASLY'
(Other definitions for measly that I've seen before include "Insignificant a having spots!" , "Paltry - with spots?" , "Ridiculously small" , "Slay me (anag)" , "Spotty - paltry" .)