Miserable meeting first vicious man (6)
I believe the answer is:
sadist
'vicious man' is the definition.
(someone who enjoys inflicting pain)
'miserable meeting first' is the wordplay.
'miserable' becomes 'sad' (similar in meaning).
'meeting' is a charade indicator (letters next to each other).
'first' becomes 'ist'.
'sad'+'ist'='SADIST'
(Other definitions for sadist that I've seen before include "Savage'!?" , "One enjoying inflicting pain" , "Person who likes to inflict pain" , "One gaining pleasure from inflicting pain on another" , "Someone who finds pleasure in hurting others" .)