Miserable wife was sick (8)
I believe the answer is:
wretched
'miserable' is the definition.
(synonyms)
'wife was sick' is the wordplay.
'wife' becomes 'w'.
'was sick' becomes 'retched' (I can't justify this - if you can you should believe this answer much more).
'w'+'retched'='WRETCHED'
Can you help me to learn more?
(Other definitions for wretched that I've seen before include "Pitiful" , "Poor" , "Abject" , "Hapless" , "misery" .)