Misery caused by spinning of a spider (7)
I believe the answer is:
despair
'misery' is the definition.
(I've seen this before)
'spinning of a spider' is the wordplay.
'spinning of' is an anagram indicator.
'a'+'spider'='aspider'
'aspider' is an anagram of 'DESPAIR'.
'caused by' is the link.
(Other definitions for despair that I've seen before include "Feeling of hopelessness" , "A spider (anag.)" , "Give up hope" , "Be without hope" , "Lose or lack hope" .)