Misery of George III’s condition, after initial change (7)
I believe the answer is:
sadness
'misery' is the definition.
(both can mean unhappiness)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for sadness that I've seen before include "no joy there" , "Sorrowful quality" , "Grief" , "Dolour" , "regret" .)