Crossword Genius

Misery of George III’s condition, after initial change (7)

Ross

I believe the answer is:

sadness

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'misery' is the definition.
(both can mean unhappiness)

I can't explain the rest of the clue.

Can you help me to learn more?

(Other definitions for sadness that I've seen before include "no joy there" , "Sorrowful quality" , "Grief" , "Dolour" , "regret" .)

I've seen this clue in The Times.
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