Misery strangely praised (7)
I believe the answer is:
despair
'misery' is the definition.
(I've seen this before)
'strangely praised' is the wordplay.
'strangely' indicates anagramming the letters.
'praised' anagrammed gives 'DESPAIR'.
(Other definitions for despair that I've seen before include "Lose heart" , "Praised (anag) - lose hope" , "Misery" , "Smashed up" , "State of having lost all hope" .)