Misguided sour smile (3-4)
I believe the answer is:
off-beam
'misguided' is the definition.
(I've seen this before)
'sour smile' is the wordplay.
'sour' becomes 'off' (synonyms).
'smile' becomes 'beam' (to beam is to smile).
'off'+'beam'='OFF-BEAM'
(Other definitions for off-beam that I've seen before include "Mistaken" , "On the wrong track; awry" , "Inaccurate or misguided" , "Wrong (navigation)" , "On the wrong track (colloq.)" .)