Miss Italy left you in charge (7)
I believe the answer is:
failure
'miss' is the definition.
(I've seen this before)
'italy left you in charge' is the wordplay.
'italy' becomes 'i'.
'left you' becomes 'lu' (I can't explain this - if you can you should give a lot more credence to this answer).
'in' is an insertion indicator.
'charge' becomes 'fare' (fare is a kind of charge).
'i'+'lu'='ilu'
'ilu' inserted inside 'fare' is 'FAILURE'.
Can you help me to learn more?
(Other definitions for failure that I've seen before include "Lack of success, or he who lacks it" , "Defeat" , "miss" , "[OPPOSITE OF] success" , "No-hoper" .)