Mixed lone dose and relaxed (8)
I believe the answer is:
loosened
'relaxed' is the definition.
('loosen' can be a synonym of 'relax')
'mixed lone dose' is the wordplay.
'mixed' indicates an anagram.
'lone'+'dose'='lonedose'
'lonedose' with letters rearranged gives 'LOOSENED'.
'and' is the link.
(Another definition for loosened that I've seen is " Made slack, eased as with grip".)
I've seen this clue in The Mirror.
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