Modifying integral structure (8)
I believe the answer is:
altering
'modifying' is the definition.
(thesaurus)
'integral structure' is the wordplay.
'structure' indicates anagramming the letters.
'integral' with letters rearranged gives 'ALTERING'.
(Other definitions for altering that I've seen before include "making a change" , "Changing -- 1 across (anag)" , "Making changes" , "Modifying, changing" , "revising" .)