Mole excited by new fruit (5)
I believe the answer is:
melon
'fruit' is the definition.
(type of fruit)
'mole excited by new' is the wordplay.
'excited' is an anagram indicator.
'by' is a charade indicator (letters next to each other).
'new' becomes 'n' (common abbreviation eg NT for New Testament).
'mole' with letters rearranged gives 'melo'.
'melo'+'n'='MELON'
(Other definitions for melon that I've seen before include "Type of pepo" , "Fruit - lemon (anag)" , "Killing" , "Cantaloupe fruit" , "I'm very seedy" .)