More than a barrel can kill you!
I believe the answer is:
gun
'can kill you' is the definition.
The answer and definition can be both man-made objects as well as being singular nouns.
Perhaps you can see a link between them that I can't see?
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for gun that I've seen before include "Arm" , "It can be carried by 15 Ac" , "What has barrel" , "Revolver" , "An offensive weapon" .)