Most are maddened with genius (7)
I believe the answer is:
maestro
'genius' is the definition.
(I've seen this before)
'most are maddened' is the wordplay.
'most are' anagrams to 'MAESTRO'.
Though, I am unsure how the anagram is indicated.
'with' is the link.
Can you help me to learn more?
(Other definitions for maestro that I've seen before include "Accomplished musician" , "Highly talented figure in a given field" , "A master of any art, like music" , "Expert in music etc" , "Distinguished composer, conductor or performer" .)