Most circumspect, using ears and wit (7)
I believe the answer is:
wariest
'most circumspect' is the definition.
Both the answer and definition are superlative adjectives. Perhaps there's a link between them I don't understand?
'using ears and wit' is the wordplay.
'using' indicates an anagram (the letters used in a different way).
'and' means one lot of letters go next to another.
'ears' put after 'wit' is 'witears'.
'witears' is an anagram of 'WARIEST'.
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